To make comic strips or webcomics you should read a lot of comics and books.
Just by having fun and supporting other artists you'll start to understand how a story flows, how to create drama and how to use the lines and panels to get do more.
Also you'll find the best genre or format for you comic.
2... 3... or 4... panel comic strip:
I'm a fan of several comics so here are some examples ( I do not own the following images)
The first panel is all about CONTEXT :
WHO or WHAT and WHERE, WHEN, WHY, HOW...
The second and third develop the first panel ( goal and conflict).
The fouth pannel is CONCLUSION, that's where the joke usually is.
1- Monica tries to hit Jimmy Five with her bunny outside.
2- Her goal is stopped by Jimmy Five's suggestion.
3- She can't use the bunny. So what will she use?
4- The misunderstanding and she's back to her goal.